In this talk intended for the astronomy mini-symposium, I will highlight how capabilities in Astropy are used to solve computational problems in two current projects. Coordinate matching, world coordinate systems, and data manipulation are used heavily in parts of the data system for the Zwicky Transient Facility, which processes 1 terabyte of images per night, within 10 minutes of receipt of each exposure. Astropy units and quantities, and the cosmology module, enabled the rapid development of a web application for the proposed Origins Space Telescope.

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